Increased Activation of the TRESK K⁺ Mediates Vago-Vagal Reflex Malfunction in Diabetic Rats.

ABSTRACT:

Background & aims

Patients with diabetes have defects in the vagal afferent pathway that result in abnormal gastrointestinal function. We investigated whether selective increased activation of the 2-pore domain potassium channel TRESK (2-pore-domain weak inward-rectifying potassium channel-related spinal cord potassium channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in diabetic rats.

Methods

We conducted whole-cell current-clamp and single-unit recordings in NG neurons from diabetes-prone BioBreeding/Worcester rats and streptozotocin-induced diabetic (STZ-D) rats and compared them with control rats. NG neurons in rats or cultured NG neurons were exposed to pharmacologic antagonists and/or transfected with short hairpin or small i

SUBMITTER: Grabauskas G 

PROVIDER: S-EPMC5159314 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature