Recent Advances in Chemotherapy and Surgery for Colorectal Liver Metastases.

ABSTRACT:

Background

The liver is the most common site of metastases for colorectal cancer, and combined resection with systemic chemotherapy is the most effective strategy for survival. The aim of this article is to provide a comprehensive summary on four hot topics related to chemotherapy and surgery for colorectal liver metastases (CLM), namely: (1) chemotherapy-related liver injuries: prediction and impact, (2) surgery for initially unresectable CLM, (3) the emerging role of RAS mutations, and (4) the role of hepatic arterial infusion of chemotherapy (HAIC).

Summary and key messages

(1) The use of chemotherapy before liver resection for CLM leads to drug-specific hepatic toxicity, which negatively impacts posthepatectomy outcomes. (2) Curative liver resection of initially u

SUBMITTER: Passot G 

PROVIDER: S-EPMC5159720 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature