Co-expression analysis and identification of fecundity-related long non-coding RNAs in sheep ovaries.

ABSTRACT: Small Tail Han sheep, including the FecB^BFecB^B (Han BB) and FecB⁺ FecB⁺ (Han++) genotypes, and Dorset sheep exhibit different fecundities. To identify novel long non-coding RNAs (lncRNAs) associated with sheep fecundity to better understand their molecular mechanisms, a genome-wide analysis of mRNAs and lncRNAs from Han BB, Han++ and Dorset sheep was performed. After the identification of differentially expressed mRNAs and lncRNAs, 16 significant modules were explored by using weighted gene coexpression network analysis (WGCNA) followed by functional enrichment analysis of the genes and lncRNAs in significant modules. Among these selected modules, the yellow and brown modules were significantly related to sheep fecundity. lncRNAs (e.g., NR0B1, XL

SUBMITTER: Miao X 

PROVIDER: S-EPMC5159859 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature