Angiopoietin 2 signaling plays a critical role in neural crest cell migration.

ABSTRACT:

Background

Collective neural crest cell migration is critical to the form and function of the vertebrate face and neck, distributing bone, cartilage, and nerve cells into peripheral targets that are intimately linked with head vasculature. The vasculature and neural crest structures are ultimately linked, but when and how these patterns develop in the early embryo are not well understood.

Results

Using in vivo imaging and sophisticated cell behavior analyses, we show that quail cranial neural crest and endothelial cells share common migratory paths, sort out in a dynamic multistep process, and display multiple types of motion. To better understand the underlying molecular signals, we examined the role of angiopoietin 2 (Ang2), which we found expressed in migrating cranial ne

SUBMITTER: McKinney MC 

PROVIDER: S-EPMC5159958 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature