Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.

ABSTRACT:

Background

Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to define and validate, for the first time ever, clinically driven asthma phenotypes using two independent, severe asthma cohorts: ADEPT and U-BIOPRED.

Methods

Fuzzy partition-around-medoid clustering was performed on pre-specified data from the ADEPT participants (n = 156) and independently on data from a subset of U-BIOPRED asthma participants (n = 82) for whom the same variables were available. Models for cluster classification probabilities were derived and appli

SUBMITTER: Loza MJ 

PROVIDER: S-EPMC5159977 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature