Menopausal hormone therapy and mortality among endometrial cancer patients in the NIH-AARP Diet and Health Study.

ABSTRACT:

Background

While menopausal hormone therapy (MHT) is an established endometrial cancer risk factor, its relationship with mortality among endometrial cancer patients is understudied.

Methods

Within the NIH-AARP Diet and Health Study, we examined the associations of pre-diagnosis MHT use with 10-year all-cause and endometrial cancer-specific mortality among 890 endometrial cancer patients. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) adjusted for tumor characteristics, treatment, and other risk factors.

Results

Endometrial cancer cases were diagnosed a median of 4.6 years (range 0.0-10.1 years) after the second risk factor questionnaire was completed. We identified a total of 241 deaths, of which

SUBMITTER: Felix AS 

PROVIDER: S-EPMC5160007 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature