Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia.

ABSTRACT:

Background

Farnesyl protein transferase inhibitors (FTIs) were originally developed to inhibit oncogenic ras, however it is now clear that there are several other potential targets for this drug class. The FTI tipifarnib (ZARNESTRA, R115777) has recently demonstrated clinical responses in adults with refractory and relapsed acute leukemias. This study was conducted to identify genetic markers and pathways that are regulated by tipifarnib in acute myeloid leukemia (AML).

Methods

Tipifarnib-mediated gene expression changes in 3 AML cell lines and bone marrow samples from two patients with AML were analyzed on a cDNA microarray containing approximately 7000 human genes. Pathways associated with these expression changes were identified using the Ingenuity Pathway Analysis tool.<

SUBMITTER: Raponi M 

PROVIDER: S-EPMC516036 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature