Rational design of DNA sequences for nanotechnology, microarrays and molecular computers using Eulerian graphs.

ABSTRACT: Nucleic acids are molecules of choice for both established and emerging nanoscale technologies. These technologies benefit from large functional densities of 'DNA processing elements' that can be readily manufactured. To achieve the desired functionality, polynucleotide sequences are currently designed by a process that involves tedious and laborious filtering of potential candidates against a series of requirements and parameters. Here, we present a complete novel methodology for the rapid rational design of large sets of DNA sequences. This method allows for the direct implementation of very complex and detailed requirements for the generated sequences, thus avoiding 'brute force' filtering. At the same time, these sequences have narrow distributions of melting temperatures. The molecula

SUBMITTER: Pancoska P 

PROVIDER: S-EPMC516071 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature