The impact of surgery, radiation, and systemic treatment on outcomes in patients with ductal carcinoma in situ.

ABSTRACT:

Background

Ductal carcinoma in situ (DCIS) is associated with low rates of mortality. Outcomes are generally assessed in terms of recurrence.

Methods

Published studies were abstracted from MEDLINE and other sources. We include articles published through January 31, 2009; 10 publications of five randomized controlled trials and 133 publications of 64 observational studies were reviewed.

Results

Whole-breast radiation therapy following breast-conserving surgery (BCS) was consistently associated with a reduced incidence of local DCIS recurrence and local invasive carcinoma. Women undergoing mastectomy were less likely than women undergoing lumpectomy with or without radiation to experience local DCIS or invasive recurrence. Tamoxifen use reduced risk of recurrent DCIS or

SUBMITTER: Kane RL 

PROVIDER: S-EPMC5161061 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature