Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.

ABSTRACT:

Background

Mutations in SCN2B, encoding voltage-gated sodium channel β2-subunits, are associated with human cardiac arrhythmias, including atrial fibrillation and Brugada syndrome. Because of this, we propose that β2-subunits play critical roles in the establishment or maintenance of normal cardiac electric activity in vivo.

Methods and results

To understand the pathophysiological roles of β2 in the heart, we investigated the cardiac phenotype of Scn2b null mice. We observed reduced sodium and potassium current densities in ventricular myocytes, as well as conduction slowing in the right ventricular outflow tract region. Functional reentry, resulting from the interplay between slowed conduction, prolonged repolarization, and increased incidence of premature ventricular compl

SUBMITTER: Bao Y 

PROVIDER: S-EPMC5161227 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature