Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia.

ABSTRACT: Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-wide association studies (GWAS) have identified many schizophrenia-associated common variants. For most of the reported associations, however, the underlying biological mechanisms are not clear. The critical first step for their elucidation is to identify the most likely disease genes as the source of the association signals. Here, we describe a general computational framework of post-GWAS analysis for complex disease gene prioritization. We identify 132 putative schizophrenia risk genes in 76 risk regions spanning 120 schizophrenia-associated common variants, 78 of which have not been recognized as schizophrenia disease genes by previous GWAS. Even more significantly, 29 of them are outside the risk re

SUBMITTER: Lin JR 

PROVIDER: S-EPMC5161287 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature