A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG.

ABSTRACT:

Background

Osteosarcoma (OS) is the most common malignant pediatric bone tumor. The identification of novel biomarkers for early prognostication will facilitate risk-based stratification and therapy. This study investigated the significance of circulating cytokines/chemokines for predicting the prognosis at the initial diagnosis.

Methods

Luminex assays were used to measure cytokine/chemokine concentrations in blood samples from a discovery cohort of OS patients from Texas Children's Hospital (n = 37) and an independent validation cohort obtained from the Children's Oncology Group (n = 233). After the validation of the biomarkers, a multivariate model was constructed to stratify the patients into risk groups.

Results

The circulating concentrations of C-X-C motif chemok

SUBMITTER: Flores RJ 

PROVIDER: S-EPMC5161556 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature