The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

ABSTRACT:

Purpose

To provide further insight into the role of proliferation and other cellular processes in chemosensitivity and resistance, we evaluated the association of a diverse set of gene expression signatures with response to neoadjuvant chemotherapy (NAC) in breast cancer.

Experimental design

Expression data from primary breast cancer biopsies for 1,419 patients in 17 studies prior to NAC were identified and aggregated using common normalization procedures. Clinicopathologic characteristics, including response to NAC, were collected. Scores for 125 previously published breast cancer-related gene expression signatures were calculated for each tumor.

Results

Within each receptor-based subgroup or PAM50 subtype, breast tumors with high proliferation signature scores were

SUBMITTER: Stover DG 

PROVIDER: S-EPMC5161615 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature