Designing and screening of universal drug from neem (Azadirachta indica) and standard drug chemicals against influenza virus nucleoprotein.

ABSTRACT:

Background

Different strains of influenza virus are affecting a large number of people worldwide. Many synthetic antiviral medicines are available for influenza virus in the market. But still there is a need for the development of universal drugs against these strains of influenza virus.

Methods

For this purpose conserved residues within the influenza virus nucleoprotein have been retrieved. The drugs, previously known to have antiviral properties, were screened to identify the best candidate universal drug against Influenza virus strains. Compounds from leaf extracts of neem, were also screened to identify the natural drugs without side effects.

Result

Molecular docking identified three potential compounds (Nimbaflavone, Rutin, and Hyperoside) having perfect binding

SUBMITTER: Ahmad A 

PROVIDER: S-EPMC5162082 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature