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Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1.

ABSTRACT: Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children.

SUBMITTER: Canobio S 

PROVIDER: S-EPMC516277 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature

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Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1.

Canobio Sophie S   Guilbert Cynthia M CM   Troesch Myriam M   Samson Johanne J   Lemay Mireille M   Pelletier Veronique Anne VA   Bernard-Bonnin Anne-Claude AC   Kozielski Rafal R   Lapointe Normand N   Martin Steven R SR   Soudeyns Hugo H  

Journal of clinical microbiology 20040901 9

Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children. ...[more]

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