Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.

ABSTRACT:

Objective

Aortic surgeries requiring hypothermic circulatory arrest evoke systemic inflammatory responses that often manifest as vasoplegia and hypotension. Because mast cells can rapidly release vasoactive and proinflammatory effectors, we investigated their role in intraoperative hypotension.

Methods

We studied 31 patients undergoing proximal aortic repair with hypothermic circulatory arrest between June 2013 and April 2015 at Duke University Medical Center. Plasma samples were obtained at different intraoperative time points to quantify chymase, interleukin-6, interleukin-8, tumor necrosis factor alpha, and white blood cell CD11b expression. Hypotension was defined as the area (minutes × millimeters mercury) below a mean arterial pressure of 55 mm Hg. Biomarker responses

SUBMITTER: Kertai MD 

PROVIDER: S-EPMC5164847 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature