Airway pressure release ventilation during ex vivo lung perfusion attenuates injury.

ABSTRACT:

Objective

Critical organ shortages have resulted in ex vivo lung perfusion gaining clinical acceptance for lung evaluation and rehabilitation to expand the use of donation after circulatory death organs for lung transplantation. We hypothesized that an innovative use of airway pressure release ventilation during ex vivo lung perfusion improves lung function after transplantation.

Methods

Two groups (n = 4 animals/group) of porcine donation after circulatory death donor lungs were procured after hypoxic cardiac arrest and a 2-hour period of warm ischemia, followed by a 4-hour period of ex vivo lung perfusion rehabilitation with standard conventional volume-based ventilation or pressure-based airway pressure release ventilation. Left lungs were subsequently transplanted into r

SUBMITTER: Mehaffey JH 

PROVIDER: S-EPMC5164862 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature