Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype.

ABSTRACT:

Objective

This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants.

Design

Cross-sectional study.

Participants

We included 111 older adults (80 with LLD and 31 comparison participants) in this study.

Measurement

A panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants. We conducted a principal component analysis to create the SASP index based on individual weights of each of protein.

Results

Participants with LLD showed a significantly increased SASP index compared with comparison participants,

SUBMITTER: Diniz BS 

PROVIDER: S-EPMC5164865 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature