T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments.

ABSTRACT: It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell lineages and their interactions are being sought. Here we studied a mouse model of human T-cell acute lymphoblastic leukaemia (T-ALL) and used intravital microscopy to monitor the progression of disease within the bone marrow at both the tissue-wide and single-cell level over time, from bone marrow seeding to development/selection of chemo-resistance. We observed highly dynamic cellular interactions and promiscuous distribution of leukaemia cells that migrated across the bone marrow, without showing

SUBMITTER: Hawkins ED 

PROVIDER: S-EPMC5164929 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature