Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons.

ABSTRACT: Dorsal root ganglion (DRG) neurons are important relay stations between the periphery and the central nervous system and are essential for somatosensory signaling. Reactive species are produced in a variety of physiological and pathophysiological conditions and are known to alter electric signaling. Here we studied the influence of reactive species on the electrical properties of DRG neurons from mice with the whole-cell patch-clamp method. Even mild stress induced by either low concentrations of chloramine-T (10 μM) or low-intensity blue light irradiation profoundly diminished action potential frequency but prolonged single action potentials in wild-type neurons. The impact on evoked action potentials was much smaller in neurons deficient of the tetrodotoxin (TTX)-resistant voltage-gated

SUBMITTER: Schink M 

PROVIDER: S-EPMC5165275 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature