Altered Cytoskeleton as a Mitochondrial Decay Signature in the Retinal Pigment Epithelium.

ABSTRACT: Mitochondria mediate energy metabolism, apoptosis, and aging, while mitochondrial disruption leads to age-related diseases that include age-related macular degeneration. Descriptions of mitochondrial morphology have been non-systematic and qualitative, due to lack of knowledge on the molecular mechanism of mitochondrial dynamics. The current study analyzed mitochondrial size, shape, and position quantitatively in retinal pigment epithelial cells (RPE) using a systematic computational model to suggest mitochondrial trafficking under oxidative environment. Our previous proteomic study suggested that prohibitin is a mitochondrial decay biomarker in the RPE. The current study examined the prohibitin interactome map using immunoprecipitation data to determine the indirect signaling on cytoskele

SUBMITTER: Sripathi SR 

PROVIDER: S-EPMC5165655 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature