A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis.

ABSTRACT: Previously, we described the AtGRF [Arabidopsis thaliana growth-regulating factor (GRF)] gene family, which encodes putative transcription factors that play a regulatory role in growth and development of leaves and cotyledons. We demonstrate here that the C-terminal region of GRF proteins has transactivation activity. In search of partner proteins for GRF1, we identified another gene family, GRF-interacting factor (GIF), which comprises three members. Sequence and molecular analysis showed that GIF1 is a functional homolog of the human SYT transcription coactivator. We found that the N-terminal region of GIF1 protein was involved in the interaction with GRF1. To understand the biological function of GIF1, we isolated a loss-of-function mutant of GIF1 and prepared transgenic plants subject

SUBMITTER: Kim JH 

PROVIDER: S-EPMC516574 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature