Transcription regulation by the Mycobacterium tuberculosis alternative sigma factor SigD and its role in virulence.

ABSTRACT: Mycobacterium tuberculosis, an obligate mammalian pathogen, adapts to its host during the course of infection via the regulation of gene expression. Of the regulators of transcription that play a role in this response, several alternative sigma factors of M. tuberculosis have been shown to control gene expression in response to stresses, and some of these are required for virulence or persistence in vivo. For this study, we examined the role of the alternative sigma factor SigD in M. tuberculosis gene expression and virulence. Using microarray analysis, we identified several genes whose expression was altered in a strain with a sigD deletion. A small number of these genes, including sigD itself, the gene encoding the autocrine growth factor RpfC, and a gene of unknown function, Rv1815, app

SUBMITTER: Raman S 

PROVIDER: S-EPMC516600 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature