Genetic associations of the interleukin locus at 1q32.1 with clinical outcomes of cutaneous melanoma.

ABSTRACT:

Background

Due to high melanoma immunogenicity, germline genetic variants in immune pathways have been studied for association with melanoma prognosis. However, limited candidate selection, inadequate power, or lack of independent validation have hampered the reproducibility of these prior findings, preventing personalised clinical applicability in melanoma prognostication. Our objective was to assess the prognostic utility of genetic variants in immunomodulatory pathways for prediction of melanoma clinical outcomes.

Methods

We genotyped 72 tag single nucleotide polymorphisms (SNPs) in 44 immunomodulatory genes in a population sample of 1022 melanoma patients and performed Cox regression analysis to test the association between SNPs and melanoma recurrence-free (RFS) and ove

SUBMITTER: Rendleman J 

PROVIDER: S-EPMC5166523 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature