The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system.

ABSTRACT: We report an electro-nanofluidic membrane for tunable, ultra-low power drug delivery employing an ionic field effect transistor. Therapeutic release from a drug reservoir was successfully modulated, with high energy efficiency, by actively adjusting the surface charge of slit-nanochannels 50, 110, and 160 nm in size, by the polarization of a buried gate electrode and the consequent variation of the electrical double layer in the nanochannel. We demonstrated control over the transport of ionic species, including two relevant hypertension drugs, atenolol and perindopril, that could benefit from such modulation. By leveraging concentration-driven diffusion, we achieve a 2 to 3 order of magnitude reduction in power consumption as compared to other electrokinetic phenomena. The application of a

SUBMITTER: Bruno G 

PROVIDER: S-EPMC5166607 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature