Human leucocyte antigen class I-redirected anti-tumour CD4⁺ T cells require a higher T cell receptor binding affinity for optimal activity than CD8⁺ T cells.

ABSTRACT: CD4⁺ T helper cells are a valuable component of the immune response towards cancer. Unfortunately, natural tumour-specific CD4⁺ T cells occur in low frequency, express relatively low-affinity T cell receptors (TCRs) and show poor reactivity towards cognate antigen. In addition, the lack of human leucocyte antigen (HLA) class II expression on most cancers dictates that these cells are often unable to respond to tumour cells directly. These deficiencies can be overcome by transducing primary CD4⁺ T cells with tumour-specific HLA class I-restricted TCRs prior to adoptive transfer. The lack of help from the co-receptor CD8 glycoprotein in CD4⁺ cells might result in these cells requiring a different optimal TCR binding affinity. Here we compared prima

SUBMITTER: Tan MP 

PROVIDER: S-EPMC5167017 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature