Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.

ABSTRACT: Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be

SUBMITTER: Roy E 

PROVIDER: S-EPMC5167353 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature