Angiotensin Converting Enzyme Regulates Cell Proliferation and Migration.

ABSTRACT:

Background

The angiotensin-I converting enzyme (ACE) plays a central role in the renin-angiotensin system, acting by converting the hormone angiotensin-I to the active peptide angiotensin-II (Ang-II). More recently, ACE was shown to act as a receptor for Ang-II, and its expression level was demonstrated to be higher in melanoma cells compared to their normal counterparts. However, the function that ACE plays as an Ang-II receptor in melanoma cells has not been defined yet.

Aim

Therefore, our aim was to examine the role of ACE in tumor cell proliferation and migration.

Results

We found that upon binding to ACE, Ang-II internalizes with a faster onset compared to the binding of Ang-II to its classical AT1 receptor. We also found that the complex Ang-II/ACE translocates

SUBMITTER: Alvarenga EC 

PROVIDER: S-EPMC5167550 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature