Single-dose T3 administration: kinetics and effects on biochemical and physiological parameters.

ABSTRACT:

Background

As changes in thyroid stimulating hormone (TSH), thyroid hormones, and vital signs after administration of a single dose of liothyronine have typically only been documented for 24 hours, we documented these parameters more than 96 hours.

Methods

Blood samples were obtained for 4 days after administration of 50-mcg liothyronine to 12 healthy euthyroid participants. Concentrations of total and free triiodothyronine, free and total thyroxine, and TSH were measured. Vital signs were documented.

Results

Triiodothyronine concentrations peaked at 2.5 hours after liothyronine administration. Heart rate (HR) increased by 5 hours after liothyronine administration, subsequently reaching a value higher than baseline (P = 0.009). Suppression of TSH concentrations began

SUBMITTER: Jonklaas J 

PROVIDER: S-EPMC5167556 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature