Synergy Between Tissue Factor and Exogenous Factor XIa in Initiating Coagulation.

ABSTRACT:

Objective

Recent evidence suggests involvement of coagulation factor XIa (FXIa) in thrombotic event development. This study was conducted to explore possible synergies between tissue factor (TF) and exogenous FXIa (E-FXIa) in thrombin generation.

Approach and results

In thrombin generation assays, for increasing concentrations of E-FXIa with low, but not with high TF concentrations, peak thrombin significantly increased whereas lag time and time to peak significantly decreased. Similar dependencies of lag times and rates of thrombin generation were found in mathematical model simulations. In both in vitro and in silico experiments that included E-FXIa, thrombin bursts were seen for TF levels much lower than those required without E-FXIa. For in silico thrombin bursts initiat

SUBMITTER: Leiderman K 

PROVIDER: S-EPMC5167573 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature