A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?

ABSTRACT: The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, strik

SUBMITTER: Wisse LEM 

PROVIDER: S-EPMC5167633 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature