Post-transcriptional gene regulation by mRNA modifications.

ABSTRACT: The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N⁶-methyladenosine (m⁶A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation. N⁶-adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes such as cell differentiation, embryonic development and stress responses. Other mRNA modifications, including N¹-methyladenosine (m¹A), 5-methylcytosine (m⁵C) and pseudouridine, together with m⁶A form the epitranscriptome and collectively

SUBMITTER: Zhao BS 

PROVIDER: S-EPMC5167638 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature