Structural quality of unrefined models in protein docking.

ABSTRACT: Structural characterization of protein-protein interactions is essential for understanding life processes at the molecular level. However, only a fraction of protein interactions have experimentally resolved structures. Thus, reliable computational methods for structural modeling of protein interactions (protein docking) are important for generating such structures and understanding the principles of protein recognition. Template-based docking techniques that utilize structural similarity between target protein-protein interaction and cocrystallized protein-protein complexes (templates) are gaining popularity due to generally higher reliability than that of the template-free docking. However, the template-based approach lacks explicit penalties for intermolecular penetration, as opposed to

SUBMITTER: Anishchenko I 

PROVIDER: S-EPMC5167671 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature