Temporal Regulation of the Transformasome and Competence Development in Streptococcus suis.

ABSTRACT: In S. suis the ComX-inducing peptide (XIP) pheromone regulates ComR-dependent transcriptional activation of comX (or sigX) the regulator of the late competence regulon. The aims of this study were to identify the ComR-regulated genes and in S. suis using genome-wide transcriptomics and identify their function based on orthology and the construction of specific knockout mutants. The ComX regulon we identified, includes all homologs of the "transformasome" a type 4-like pilus DNA binding and transport apparatus identified in Streptococcus pneumoniae, Streptococcus mutans, and Streptococcus thermophilus. A conserved CIN-box (YTACGAAYW), predicted to be bound by ComX, was found in the promoters of operons encoding genes involved in expression of the tr

SUBMITTER: Zaccaria E 

PROVIDER: S-EPMC5167698 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature