On the Role of CD8⁺ T Cells in Determining Recovery Time from Influenza Virus Infection.

ABSTRACT: Myriad experiments have identified an important role for CD8⁺ T cell response mechanisms in determining recovery from influenza A virus infection. Animal models of influenza infection further implicate multiple elements of the immune response in defining the dynamical characteristics of viral infection. To date, influenza virus models, while capturing particular aspects of the natural infection history, have been unable to reproduce the full gamut of observed viral kinetic behavior in a single coherent framework. Here, we introduce a mathematical model of influenza viral dynamics incorporating innate, humoral, and cellular immune components and explore its properties with a particular emphasis on the role of cellular immunity. Calibrated against a range of murine data, our model

SUBMITTER: Cao P 

PROVIDER: S-EPMC5167728 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature