Influence of preinfarction angina and coronary collateral blood flow on the efficacy of remote ischaemic conditioning in patients with ST segment elevation myocardial infarction: post hoc subgroup analysis of a randomised controlled trial.

ABSTRACT:

Objectives

Remote ischaemic conditioning (RIC) confers cardioprotection in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). We investigated whether preinfarction angina and coronary collateral blood flow (CCBF) to the infarct-related artery modify the efficacy of RIC.

Design

Post hoc subgroup analysis of a randomised controlled trial.

Participants

A total of 139 patients with STEMI randomised to treatment with pPCI or RIC+pPCI.

Interventions

RIC was performed prior to pPCI as four cycles of 5 min upper arm ischaemia and reperfusion with a blood pressure cuff.

Primary outcome measure

Myocardial salvage index (MSI) assessed by single-photon emission computerised tomography. We ev

SUBMITTER: Pryds K 

PROVIDER: S-EPMC5168541 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature