Ontology highlight
ABSTRACT:
SUBMITTER: Rao K
PROVIDER: S-EPMC5170858 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Rao Kavitha K Stone Michelle C MC Weiner Alexis T AT Gheres Kyle W KW Zhou Chaoming C Deitcher David L DL Levitan Edwin S ES Rolls Melissa M MM
Molecular biology of the cell 20160907 21
Mutations in >50 genes, including spastin and atlastin, lead to hereditary spastic paraplegia (HSP). We previously demonstrated that reduction of spastin leads to a deficit in axon regeneration in a Drosophila model. Axon regeneration was similarly impaired in neurons when HSP proteins atlastin, seipin, and spichthyin were reduced. Impaired regeneration was dependent on genetic background and was observed when partial reduction of HSP proteins was combined with expression of dominant-negative mi ...[more]