Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.

ABSTRACT:

Background

Grade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results.

Methods

We included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karn

SUBMITTER: Buckner JC 

PROVIDER: S-EPMC5170873 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature