Validity of using ad hoc methods to analyze secondary traits in case-control association studies.

ABSTRACT: Case-control association studies often collect from their subjects information on secondary phenotypes. Reusing the data and studying the association between genes and secondary phenotypes provide an attractive and cost-effective approach that can lead to discovery of new genetic associations. A number of approaches have been proposed, including simple and computationally efficient ad hoc methods that ignore ascertainment or stratify on case-control status. Justification for these approaches relies on the assumption of no covariates and the correct specification of the primary disease model as a logistic model. Both might not be true in practice, for example, in the presence of population stratification or the primary disease model following a probit model. In this paper, we investigate th

SUBMITTER: Yung G 

PROVIDER: S-EPMC5170877 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature