Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.

ABSTRACT: The gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sister chromatid cohesion in Drosophila and human cells, yet, more recently, it was also suggested to be a negative regulator of microtubule polymerization through internal acetylation of beta Tubulin. We used genetic and biochemical approaches to clarify the function of Naa50/San during development. Our work suggests that Naa50/San is required during tissue proliferation for the correct interaction between the cohesin subunits Scc1 and Smc3. Our results also suggest a working mo

SUBMITTER: Ribeiro AL 

PROVIDER: S-EPMC5171793 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature