A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate.

ABSTRACT: Acrophobia, an abnormal fear of heights, is a specific phobia characterized as apprehension cued by the occurrence or anticipation of elevated spaces. It is considered a complex trait with onset influenced by both genetic and environmental factors. Identification of genetic risk variants would provide novel insight into the genetic basis of the fear of heights phenotype and contribute to the molecular-level understanding of its aetiology. Genetic isolates may facilitate identification of susceptibility alleles due to reduced genetic heterogeneity. We took advantage of an internal genetic isolate in Finland in which a distinct acrophobia phenotype appears to be segregating in pedigrees originally ascertained for schizophrenia. We conducted parametric, nonparametric, joint linkage and linkag

SUBMITTER: Misiewicz Z 

PROVIDER: S-EPMC5171840 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature