The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts.

ABSTRACT: The plasticity of cancer cells and the fluidity of the tumor microenvironment continue to present major challenges in the comprehensive understanding of cancer that is essential to design effective treatments. The tumor interstitial fluid (TIF) encompasses the secretome and holds the key to several of the phenotypic characteristics of cancer. Difficulties in sampling this fluid have resulted in limited characterization of its components. Here we have sampled TIF from triple negative and estrogen receptor (ER)-positive human breast tumor xenografts with or without VEGF overexpression. Angiogenesis-related factors were characterized in the TIF and plasma, to understand the relationship between the TIF and plasma secretomes. Clear differences were observed between the TIF and plasma angiogeni

SUBMITTER: Dore-Savard L 

PROVIDER: S-EPMC5171865 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature