The "Intermediate" CD14⁺⁺CD16⁺ monocyte subset increases in severe peripheral artery disease in humans.

ABSTRACT: Monocytes are key players in atherosclerotic. Human monocytes display a considerable heterogeneity and at least three subsets can be distinguished. While the role of monocyte subset heterogeneity has already been well investigated in coronary artery disease (CAD), the knowledge about monocytes and their heterogeneity in peripheral artery occlusive disease (PAOD) still is limited. Therefore, we aimed to investigate monocyte subset heterogeneity in patients with PAOD. Peripheral blood was obtained from 143 patients suffering from PAOD (Rutherford stage I to VI) and three monocyte subsets were identified by flow cytometry: CD14⁺⁺CD16^- classical monocytes, CD14⁺CD16⁺⁺ non-classical monocytes and CD14⁺⁺CD16⁺ intermediate monocyte

SUBMITTER: Wildgruber M 

PROVIDER: S-EPMC5171878 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature