Alterations in the proliferative/apoptotic equilibrium in semen of adolescents with varicocele.

ABSTRACT:

Purpose

To verify if the presence of varicocele (grades II and III) with and without seminal alterations, using the 5^th centile cutoff values in table A1.1 of the World Health Organization (WHO, 2010) manual, alters the seminal plasma levels of proteins DNASE1 (deoxyribonuclease-1) and IGFBP7 (Insulin-like growth factor-binding protein 7), which are related to apoptosis regulation and cell proliferation, respectively, demonstrating that these proteins are important for correct spermatogenesis.

Methods

This cross sectional study was performed at the Sao Paulo Federal University Paulo between May 2014 and April 2016. A total of 61 male adolescents were included in this study, of which 20 controls without varicocele (C), 22 with varicocele and normal semen analysis (

SUBMITTER: Belardin LB 

PROVIDER: S-EPMC5171898 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature