Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria.

ABSTRACT: Cerebral malaria is a pathology involving inflammation in the brain. There are many immune cell types activated during this process, but there is little information on the response of microglia, in this severe complication. We examined microglia by genome wide transcriptomic analysis in a model of experimental cerebral malaria (ECM), in which C57BL/6 mice are infected with Plasmodium berghei ANKA. Thousands of transcripts were differentially expressed in microglia at two different time points during infection. Proliferation of microglia was a dominant feature before the onset of ECM, and supporting this, we observed an increase in numbers of these cells in the brain. When cerebral malaria symptoms were manifest, genes involved in immune responses and chemokine production were upregulated,

SUBMITTER: Capuccini B 

PROVIDER: S-EPMC5171943 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature