Comparative metagenomics reveals taxonomically idiosyncratic yet functionally congruent communities in periodontitis.

ABSTRACT: The phylogenetic characteristics of microbial communities associated with periodontitis have been well studied, however, little is known about the functional endowments of this ecosystem. The present study examined 73 microbial assemblages from 25 individuals with generalized chronic periodontitis and 25 periodontally healthy individuals using whole genome shotgun sequencing. Core metabolic networks were computed from taxa and genes identified in at least 80% of individuals in each group. 50% of genes and species identified in health formed part of the core microbiome, while the disease-associated core microbiome contained 33% of genes and only 1% of taxa. Clinically healthy sites in individuals with periodontitis were more aligned with sites with disease than with health. 68% of the healt

SUBMITTER: Dabdoub SM 

PROVIDER: S-EPMC5172196 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature