Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions.

ABSTRACT: The epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how tr

SUBMITTER: Kawakatsu T 

PROVIDER: S-EPMC5172462 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature