Autophagy gene expression profiling identifies a defective microtubule-associated protein light chain 3A mutant in cancer.

ABSTRACT: The cellular stress response autophagy has been implicated in various diseases including neuro-degeneration and cancer. The role of autophagy in cancer is not clearly understood and both tumour promoting and tumour suppressive effects of autophagy have been reported, which complicates the design of therapeutic strategies based on targeting the autophagy pathway. Here, we have systematically analyzed gene expression data for 47 autophagy genes for deletions, amplifications and mutations in various cancers. We found that several cancer types have frequent autophagy gene amplifications, whereas deletions are more frequent in prostate adenocarcinomas. Other cancer types such as glioblastoma and thyroid carcinoma show very few alterations in any of the 47 autophagy genes. Overall, individual au

SUBMITTER: Costa JR 

PROVIDER: S-EPMC5173052 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature