MiRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer.

ABSTRACT: Estrogen receptor-alpha (ERα) is a clinically important therapeutic target for breast cancer. However, tumors that lose ERα are less responsive to anti-estrogens such as tamoxifen. MicroRNAs (miRNAs) are small RNAs that regulate expression of their target gene and dysregulations of miRNA has been identified in many diseases including human cancer. However, only a few miRNAs associated with tamoxifen resistance has been reported. In this study, we found that lymphocyte antigen 6 complex (LY6K), which is a member of the Ly-6/μPAR superfamily and related to breast cancer progression and metastasis, is inversely correlated with ERα expression. We, for the first time, found miRNAs involved in the regulatory molecular mechanism between ERα and LY6K and related to tamoxifen susceptibility in brea

SUBMITTER: Kim YS 

PROVIDER: S-EPMC5173133 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature