Identifying G-protein coupled receptors using weighted Levenshtein distance and the nearest neighbor method.

ABSTRACT: G-protein coupled receptors (GPCRs) are a class of seven-helix transmembrane proteins that have been used in bioinformatics as the targets to facilitate drug discovery for human diseases. Although thousands of GPCR sequences have been collected, the ligand specificity of many GPCRs are still unknown and only one crystal structure of the rhodopsin-like family has been solved. Therefore, identifying GPCR types only from sequence data has become an important research issue. In this study, a novel technique for identifying GPCR types based on the weighted Levenshtein distance between two receptor sequences and the nearest neighbor method (NNM) is introduced, which can deal with receptor sequences with different lengths directly. In our experiments for classifying four classes (acetylcholine, a

SUBMITTER: Xu JH 

PROVIDER: S-EPMC5173237 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature